Supplementary Exercise 12.35 of IPS7e ------------------------------------- Power calculation for a study on weight gains of pregnant women during the third trimester of pregnancy. Three groups of women will be included, and for the planning we will assume these to be of the same size. We assume sigma=2.4 (from the previous study), and the 3 means in the populations corresponding to the groups to be: 2.6, 3.0 and 3.4. Note that only the maximal difference between group means is used by the algorithm in Minitab; other software will use all 3 values. Minitab gives: MTB > Power; SUBC> OneWay 3; SUBC> Sample 50 100 150 175 200; SUBC> MaxDifference .8; SUBC> Sigma 2.4; SUBC> GPCurve. Power and Sample Size One-way ANOVA Alpha = 0.05 Assumed standard deviation = 2.4 Factors: 1 Number of levels: 3 Maximum Sample Difference Size Power 0.8 50 0.294836 0.8 100 0.544909 0.8 150 0.733193 0.8 175 0.801385 0.8 200 0.854468 Comments: --------- The listing shows that with a sample size of 50 women per group there would be less than 33% chance of a significant result (at the 5% level). A more appropriate sample size, in terms of attaining an acceptable power, is somewhere between 150 and 200 women per group. Addendum: Calculations in Stata and R based on all three group means will give powers ranging from 0.2945 to 0.8545, thus very similar results.